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The Mouse as a Model for Hypospadias

    To study hypospadias and endocrine disruptors our lab has precisely defined the anatomy of the mouse male and female external genitalia.  We have also confirmed that the mouse has many similarirites relevant to the human penis. With matermal exposure to endorine disruptors the mouse develops hypospadias.

 
 

 

Weiss DA, Rodriguez E, Jr., Cunha T, Menshenina J, Barcellos D, Chan LY, et al. Morphology of the external genitalia of the adult male and female mice as an endpoint of sex differentiation. Molecular and cellular endocrinology. 2012 May 6;354(1-2):94-102. PubMed PMID: 21893161. Pubmed Central PMCID: 3717118.

Rodriguez E, Jr., Weiss DA, Yang JH, Menshenina J, Ferretti M, Cunha TJ, et al. New insights on the morphology of adult mouse penis. Biology of reproduction. 2011 Dec;85(6):1216-21. PubMed PMID: 21918128. Pubmed Central PMCID: 3223253.

Baskin LS, Erol A, Li Y, Liu W, Cunha GR. Urethral Seam Formation and Hypospadias. Cell Tissue Res. 2001;305:379-87.

Kim KS, Torres CR, Jr., Yucel S, Raimondo K, Cunha GR, Baskin LS. Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens. Environmental research. 2004 Mar;94(3):267-75. PubMed PMID: 15016594.

Wang MH, Baskin LS. Endocrine disruptors, genital development, and hypospadias. Journal of andrology. 2008 Sep-Oct;29(5):499-505. PubMed PMID: 18497336. Epub 2008/05/24. eng.




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